Summary of talk:
The Rugao Longevity and Ageing Study (RuLAS) is a two arm cohort. The purpose of RuLAS is to: (1) describe the prevalence, trajectories and risk factors for various age-related diseases for a comprehensive understanding of the health spectrum of older adults; (2) develop predictive models of organ aging, frailty, age-related diseases, and health longevity.
Longevity arm is a case-control design which include a longevity group of 463 longevous individuals aged 95 years and older, an elderly control group of 926 individuals aged 60-69 years, and a middle-aged control group of 463 individuals aged 40-49 years. The baseline survey of longevity arm was conducted in Dec. 2007-Feb. 2008 and was followed up for 6 years of all-cause mortality for longevity individuals. The ageing arm is an ongoing prospective longitudinal study (re-serve every 1.5 years) which includes 1,788 elderly people aged 70-84 years sampled from 31 rural community in Jiang’an township. The baseline survey (wave1) was conducted in Nov.-Dec. 2014, wave2 survey was conducted in Apri.-Jun.2016, and wave3 survey was conducted in Nov.-Dec. 2017. A large amount of phenotypes was longitudinally measured including phenotypes of age-related diseases and geriatric syndrome. Fasting blood sample was drawn for laboratory measurement and for long-term cryopreservation. In addition, follow-up of the incident and mortality of common diseases was conducted yearly through hospital records, medical insurances, and funeral records.
Based on the data of RuLAS, we conducted some epidemiological studies and found risk factors (social, behavioral, genetic) of all-cause mortality, disability, and chronic kidney disease in longevous individuals aged 95 and over. We described the prevalence of some common diseases and geriatric syndromes in older adults aged 70-84 years. We found some risk factors of frailty, decreased physical function, and cardiovascular diseases in older adults.
Xiao-feng Wang, M.D., Ph.D.
School of Life Sciences,
Research field: genetic epidemiology study of cardiovascular disease, geriatric disease, aging and longevity based on longitudinal cohort.
From year 2007 to 2014, participated in the construction of a large cohort of common chronic diseases – Taizhou longitudinal study (field investigation leader), and participated in the construction of Rugao longevity study (co-principle investigator). From 2014, initiated the construction of Rugao ageing study (principle investigator), the field survey of which had been longitudinally conducted for three waves. Published monograph “Constructing of population-based cohort: thanking and practice” (deputy editor, published by People's Medical Publishing House, 2015). As the corresponding/ co-corresponding/ first/ co-first author, published about 50 papers in SCI Journals such as J Thromb Haemost (2012), J Gerontol A Biol Sci Med Sci (2015), J Am Geriatr Soc (2015), Int J Epidemiol (2016), Age Ageing (2016), Hum Genet (2017).