Mefenamic acid may ease depressive symptoms triggered by chronic stress | Duke Kunshan University

Mefenamic acid may ease depressive symptoms triggered by chronic stress

Psychosocial stresses such as a perceived threat to one’s safety or social status are major risk factors for the onset of depression. However, biologist Chang Y. Chung and fellow researchers have discovered that depressive behaviors induced by chronic mild stresses may improve with the use of mefenamic acid, an anti-inflammatory drug used for short-term pain relief. Mefenamic acid inhibits microglia activation/phagocytosis induced by chronic stress in the hippocampus, resulting in the improvement of depressive symptoms. The findings were published by Brain Research.